Table 1.
Cytotoxicity of 3,4-dihydroisocoumarins on human tumor cell lines.
| Compound | IC50 (μM) |
|||
|---|---|---|---|---|
| A549 | HCT-15 | MCF-7/MX | H69AR | |
| 14 | >100 | >100 | >100 | >100 |
| 14a | >100 | >100 | >100 | >100 |
| 16 | 78.6 ± 2.2 | >100 | >100 | 88.5 ± 4.6 |
| 16a | 53.6 ± 5.6 | >100 | 10.6 ± 0.9 | >100 |
| (R)-19 | 47.5 ± 3.2 | 57.1 ± 7.5 | 28.1 ± 0.7 | >100 |
| (R)-19a | >100 | >100 | >100 | >100 |
| (S)-19 | 42.0 ± 3.9 | >100 | 33.5 ± 7.5 | 86.8 ± 9.2 |
| (S)-19a | >100 | >100 | 89.8 ± 4.9 | >100 |
| 6-Methoxymellein (3) | >100 | >100 | >100 | >100 |
| Angelicoin B (4) | >100 | >100 | >100 | >100 |
| 21 | >50 | >50 | >50 | >50 |
| Ellagic acid | >50 | >50 | >50 | >50 |
Data represent mean ± SEM of at least three independent experiments performed in quadruplicates.