| NIHSS deterioration or no change* (n = 78) | NIHSS improvement or NIHSS = 0* (n = 110) | ||
|---|---|---|---|
| IMAGING FINDINGS | |||
| No HT | 54 (69.2%) | 97 (88.2%) | 0.002 |
| HI | 14 (17.9%) | 7 (6.4%) | 0.013 |
| PH | 7 (9.0%) | 4 (3.6%) | 0.0124 |
| CHANGES IN THERAPEUTIC MANAGEMENT | |||
| Delayed med due to HT in FU-BI | 9 (11.5%) | 2 (1.8%) | 0.005 |
| Any change in BP management due to HT in FU-BI | 12 (15.4%) | 6 (5.4%) | 0.023 |
| Changes in therapeutic management due to HT in FU-BI | 15 (19.2%) | 7 (6.4%) | 0.007 |
| NIHSS deterioration* (n = 18) | No Change in NIHSS, NIHSS improvement or NIHSS = 0* (n = 170) | ||
| IMAGING FINDINGS | |||
| No HT | 12 (66.6%) | 144 (84.7%) | 0.053 |
| HI | 1 (5.5%) | 20 (11.8%) | 0.426 |
| PH | 5 (27.8%) | 6 (3.5%) | < 0.001 |
| CHANGES IN THERAPEUTIC MANAGEMENT | |||
| Delayed med due to HT in FU-BI | 5 (27.8%) | 6 (3.6%) | < 0.001 |
| Any change in BP management due to HT in FU-BI | 4 (22.2%) | 14 (8.2%) | 0.055 |
| Changes in therapeutic management due to HT in FU-BI | 5 (27.8%) | 17 (10%) | 0.026 |
| NIHSS deterioration, no change in NIHSS or NIHSS improvement* (n = 160) | NIHSS = 0* (n = 28) | ||
| IMAGING FINDINGS | |||
| No HT | 128 (80%) | 28 (100%) | 0.009 |
| HI | 21 (13.1%) | 0 (0%) | 0.042 |
| PH | 11 (6.9%) | 0 (0%) | 0.153 |
| CHANGES IN THERAPEUTIC MANAGEMENT | |||
| Delayed med due to HT in FU-BI | 11 (6.9%) | 0 (0%) | 0.153 |
| Any change in BP management due to HT in FU-BI | 18 (11.3%) | 0 (0%) | 0.062 |
| Changes in therapeutic management due to HT in FU-BI | 22 (13.8%) | 0 (0%) | 0.037 |
The results of dichotomiced data regarding follow-up brain imaging findings for hemorrhagic transformation and management changes are given in this table. Results are presented as p-values using Pearson Chi squared or Fisher exact test when appropriate. There was no patient with cranial surgery due to hemorrhagic transformation in follow-up brain imaging. *24 h after systemic rt-PA application; BP indicates blood pressure; Delayed Med, delayed medication for more than 48 h after intravenous thrombolysis (anti-platelet therapy or anticoagulation); FU-BI, routine follow-up brain imaging after 12–36 h; HI, Hemorrhagic infarction; HT, hemorrhagic transformation; NIHSS, National Institutes of Health Stroke Scale; PH, Parenchymal hematoma.