FIGURE 3.

Consequences of hypertension on heart metabolism and function. The figure shows how hypertension shifts fuel preference from fatty acids toward carbohydrates. AMPK, AMP kinase; β-HADH, β-hydroxy-acyl-CoA dehydrogenase; CK, creatine kinase; CS, citrate synthase; HF, heart failure; HK, hexokinase; LKB1, liver kinase B; LVH, left ventricle hypertrophy; Pcr, phosphocreatine; PDH, pyruvate dehydrogenase; PFK, phosphofructokinase; PH, phosphorylase; PKCε, protein kinase C ε; PPARα, peroxisome proliferator-activated receptor alpha.