Table 1.
Human cell therapy trials for late‐stage age‐related macular degeneration
| Disease (ClinicalTrials.gov identifier) | Phase | Cell type transplanted | Center (PI) | Sponsor |
|---|---|---|---|---|
| AMD‐GA (NCT01344993, NCT02563782, NCT02463344) | I/II | ESC‐RPE (MA09‐hRPE) | Jules Stein‐UCLA (Schwartz) Wills Eye Hospital (Regillo) Mass. Eye & Ear Infirmary (Eliott) Bascom Palmer Eye Institute (Rosenfeld) |
Astellas Pharma |
| AMD‐GA (NCT03178149) | Ib/II | ASP7317 (MA09‐hRPE) | Jules Stein‐UCLA Retina Specialty institute New Jersey Retina Mid‐Atlantic Retina |
Astellas Institute for Regenerative Medicine |
| AMD‐GA (NCT01674829) | I/II | ESC‐RPE (MA09‐hRPE) | CHA Bundang Medical Center (Song) | CHA Bio & Diostech |
| AMD‐GA (NCT03305029) | Interventional | SCNT‐ESC‐RPE | CHA Bundang Medical Center (Song) | CHA University |
| AMD‐CNV (NCT01691261, NCT03102138) | I | PF‐05206388 (ESC‐RPE on a polyester membrane) | University College London (Pfizer) | Pfizer |
| AMD‐GA or CNV (NCT02464956) | Observational | Autologous iPSC‐RPE | Moorfields Eye Hospital | Moorfields Eye Hospital NHS Foundation Trust |
| AMD‐GA (NCT02590692) | I/II | ESC‐RPE on a polymeric substrate (CPCB‐RPE1) | Retina Vitreous Associates Medical Group (Rahhal) USC Keck School of Medicine (Kashani) Southern California Desert Retina Consultants Orange County Retina Medical Group California Retina Consultants |
Regenerative Patch Technologies, LLC |
| AMD‐CNV | Interventional | Autologous iPSC‐RPE | Riken Institute for Developmental Biology (Takahashi) | Riken Institute for Developmental Biology |
| AMD (NCT00874783) | Observational | iPSCs | Hadassah Medical Organization (Reubinoff) | Hadassah Medical Organization |
| AMD‐GA (NCT02286089) | I/II | ESC‐RPE | Hadassah Ein Kerem University Hospital (Jaouni) Rabin Medical Center (Erlich) Kaplan Medical Center (Morori‐Katz) Tel Aviv Souraski Medical Center (Barak) Retina Vitreous Associates (Boyer) Byers Eye Institute (Do) Retina Consultants Medical Group (Telander) West Coast Retina Medical Group (McDonald) |
Cell Cure Neurosciences, Ltd. |
| AMD‐GA (NCT02749734) | I/II | ESC‐RPE | Southwest Hospital (yin) | Southwest Hospital, Chongqing, China |
| AMD‐GA (NCT03046407) | I/II | ESC‐RPE | First Affiliated Hospital of Zhengzhou University (Qi) | Chinese Academy of Sciences |
| AMD‐GA (NCT02755428) | I/II | ESC‐RPE | Beijing Tongren Hospital (qi) | Chinese Academy of Sciences |
| AMD‐GA (NCT02868424) | I | Fetal human RPE | First Affiliated Hospital with Nanjing Medical University (Liu) | First Affiliated Hospital with Nanjing Medical University, Nanjing, China |
| AMD‐GA (NCT02016508) | I/II | Bone marrow‐derived SCs | Al‐Azhar University (Safwat) | Al‐Azhar University |
| AMD (NNCT01920867) | Interventional | Bone marrow‐derived SCs | Retina Associates of South Florida (Weiss) | Retina Associates of South Florida |
| AMD‐GA (NCT01736059) | I | Bone marrow‐derived CD34+ SCs | University of California, Davis (Park) | University of California, Davis |
| AMD‐GA or CNV (NCT01518127) | I/II | Autologous bone marrow‐derived SCs | University of Sao Paulo, Brazil (Siqueira) | University of Sao Paulo |
| AMD‐GA (NCT01632527) | I/II | HuCNS‐SC | Retina Foundation of the Southwest Retina Vitreous Associates Medical Group Byers Eye Institute New York Eye and Ear Infirmary Retina Research Institute of Texas |
StemCells, Inc. |
| AMD‐GA (NCT01226628) | I | CNTO 2476 (umbilical tissue‐derived cells) | Wills Eye Hospital (Ho) | Janssen Research & Development, LLC |
| AMD‐GA (NCT00447954) | II | NT‐501 implant | Retina‐Vitreous Associates Medical Group Retina Group of Florida Bascom Palmer Eye Institute Ophthalmic Consultants of Boston Beaumont Eye Institute Retina Foundation of Southwest Vitreoretinal Consultants University of Utah |
Neurotech Pharmaceuticals |
Abbreviations: AMD, age‐related macular degeneration; CNV, choroidal neovascularization; ESC‐RPE, human embryonic stem cell‐derived RPE; iPSC‐RPE, human induced pluripotent stem cell‐derived RPE; GA, geographic atrophy; RPE, retinal pigment epithelium; SCNT‐ESC‐RPE, somatic cell nuclear transfer human embryonic stem cell derived‐RPE; NT‐501 implant, transformed RPE that overexpress ciliary neurotrophic factor.