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. 2019 Jan 15;8(5):478–489. doi: 10.1002/sctm.18-0178

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© 2019 The Authors. stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(A): CD44 expression (green fluorescence) in human corneal epithelial cells after treatment with complete keratinocyte serum free medium with growth factors (no treatment, control), MSC‐S, HA/CS, MSC‐S in HA/CS—scale bar 20 μm. (B): Quantification of the fluorescence intensities using ImageJ revealed that CD44 receptors are upregulated in the cells that received MSC‐S (**, p < .01) and MSC‐S in HA/CS (***, p < .001). (C): CD44 expression in rat corneas in vivo 7 days after treatment with saline, MSC‐S, HA/CS, MSC‐S in HA/CS, and uninjured/untreated corneas—scale bar 50 μm. (D): Quantification of the fluorescence intensities using ImageJ showed that CD44 receptors are upregulated in the cornea treated with MSC‐S in HA/CS (*, p < .05). Abbreviations: CS, chondroitin sulfate; HA, hyaluronic acid; MSC‐S, mesenchymal stem cells secretome.