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. 2019 Apr 16;10:309. doi: 10.3389/fphys.2019.00309

FIGURE 1.

FIGURE 1

Markers of renal injury: albuminuria (A; geometric means ± geometric SD), plasma cystatin C (B), tubulointerstitial area (C), urinary kidney injury molecule-1 (KIM-1) (D), mesangial expansion (E). Diabetes resulted in significant differences for albuminuria, plasma cystatin C, KIM-1, and mesangial expansion. While hypertensive diabetic mice had much greater albuminuria there were no significant differences between the two diabetic groups for the other measures of renal injury assessed. Cont., non-diabetic control; Diab., diabetic; Normot., normotensive BPN/3J mice; Hypert., hypertensive BPH/2J mice. n = 5–10/group except for control normotensive animals: n = 3 urinary KIM-1, n = 4 albuminuria. 2-factor ANOVA p-values: I, interaction; D, relative to diabetic status; S, relative to strain. T-test p < 0.05: ∗ vs. Cont. Normot.; † vs. Cont. Hypert.; ‡ vs. Diab; Mesangial area Cont. Hypert. vs. Diab. Hypert. p = 0.07.