Table 3.
Univariate Cox regression analysis for overall survival, disease-free survival and cancer specific survival in patients with laryngeal squamous cell cancer.
| OS | DFS | CSS | ||||
|---|---|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | |
| RDW | ||||||
| ≤12.9 | ||||||
| 12.9–13.2 | 1.41 (0.866–2.305) | 0.167 | 1.63 (0.982–2.697) | 0.059 | 1.72 (1.007–2.944) | 0.047 |
| 13.2–13.5 | 1.79 (1.433–2.243) | < 0.001 | 1.91 (1.514–2.409) | < 0.001 | 1.91 (1.484–2.456) | < 0.001 |
| >13.5 | 1.67 (1.445–1.939) | < 0.001 | 1.78 (1.525–2.070) | < 0.001 | 1.74 (1.477–2.057) | < 0.001 |
| RBC | ||||||
| < 4.29 | 1 | 1 | 1 | |||
| >4.29 | 1.009 (0.860–1.183) | 0.916 | 1.028 (0.877–1.206) | 0.731 | 1.010 (0.861–1.184) | 0.961 |
| Hg | ||||||
| >133.14 | 1 | 1 | 1 | |||
| < 133.14 | 1.338 (1.141–1.570) | < 0.001 | 1.189 (1.014–1.395) | 0.033 | 1.138 (1.141–1.570) | < 0.001 |
| RADIOTHERAPY | ||||||
| Yes | 1 | 1 | 1 | |||
| No | 1.576 (1.124–2.211) | 0.008 | 1.799 (1.283–2.524) | 0.001 | 1.556 (1.109–2.128) | 0.010 |
| CHEMOTHERAPY | ||||||
| Yes | 1 | 1 | 1 | |||
| No | 1.941 (1.176–3.024) | 0.009 | 2.191 (1.328–3.614) | 0.002 | 1.910 (1.151–3.136) | 0.012 |
| TNM STAGE | ||||||
| I-II | 1 | 1 | 1 | |||
| III-IV | 2.714 (2.033–3.621) | < 0.001 | 2.882 (2.161–3.845) | < 0.001 | 3.107 (2.291–4.212) | < 0.001 |
| T STAGE | ||||||
| T1−2 | 1 | 1 | 1 | |||
| T3−4 | 2.392 (1.798–3.176) | < 0.001 | 2.532 (1.906–3.366) | < 0.001 | 2.726 (2.026–3.673) | < 0.001 |
| N STAGE | ||||||
| N0 | ||||||
| N1 | 1 | 1 | 1 | |||
| N2−3 | 3.254 (2.124–4.785) | < 0.001 | 3.408 (2.317–5.010) | < 0.001 | 3.435 (2.320–5.13) | < 0.001 |
| TUMOR SUBSITE | ||||||
| Glottic and Subglottic | 1 | 1 | 1 | |||
| Supraglottic | 2.250 (1.654–3.003) | < 0.001 | 2.380 (1.774–3.195) | < 0.001 | 2.127 (1.654–2.967) | < 0.001 |
| OPERATION THERAPY | ||||||
| Partial laryngectomy | 1 | 1 | 1 | |||
| Total laryngectomy | 2.472 (1.881–3.255) | < 0.001 | 2.621 (1.993–3.449) | < 0.001 | 2.469 (1.877–3.244) | < 0.001 |
| TUMOR SIZE | ||||||
| ≤2 cm | 1 | 1 | 1 | |||
| >2 cm | 2.650 (1.995–3.524) | < 0.001 | 2.634 (1.980–3.500) | < 0.001 | 2.765 (2.080–3.677) | < 0.001 |
| AGE | ||||||
| < 60 | 1 | 1 | 1 | |||
| ≥60 | 1.676 (1.250–2.245) | 0.001 | 1.595 (1.190–2.136) | 0.002 | 1.569 (1.160–2.122) | 0.003 |
| BMI | ||||||
| < 23.42 | 1 | 1 | 1 | |||
| ≥23.42 | 0.861 (0.738–1.134) | 0.356 | 0.865 (0.645–1.234) | 0.322 | 0.889 (0.679–1.167) | 0.336 |
| HYPERTENSION | ||||||
| No | 1 | 1 | 1 | |||
| Yes | 1.254 (0.925–1.697) | 0.144 | 1.302 (0.963–1.766) | 0.093 | 1.219 (0.888–1.673) | 0.225 |
| SMOKING HISTORY | ||||||
| No | 1 | 1 | 1 | |||
| Yes | 1.057 (0.774–1.447) | 0.728 | 1.103 (0.805–1.508) | 0.539 | 1.105 (0.796–1.537) | 0.548 |
| DRINKING HISTORY | ||||||
| No | 1 | 1 | 1 | |||
| Yes | 1.111 (0.833–1.484) | 0.474 | 1.162 (0.871–1.554) | 0.309 | 1.139 (0.844–1.539) | 0.396 |
RDW, red cell distribution width; Hg, hemoglobin; WBC, white blood cell; RBC, red blood cell count; BMI, body mass index.