Table 2.

Biological functions of the candidate genes.

Genes	Biological functiona
lcrF, yscA, ORFC	pCD1 plasmid-derived virulence factors (Plano and Straley, 1995; Schwiesow et al., 2015)
mgtB	Mg+2 transporting ATPase (Ford et al., 2014)
iucA	Iron ion homeostasis (Forman et al., 2007)
bioD	Biotin biosynthetic process
fyuA, irp1, irp2, irp3, irp4, irp5, irp6, irp7, irp9	Iron uptake system, pgm locus (Iteman et al., 1993; deAlmeida et al., 1994; Buchrieser et al., 1999; Gaddy et al., 2014)

^aBiological functions were obtained from the Gene Ontology Consortium (www.geneontology.org), from the annotation of the Y. pestis CO92 sequence and the aforementioned references.