Figure 5.

Role of cyclin A in the anti-proliferative action of canagliflozin. (A) AdCyclin A increases cyclin A protein levels in canagliflozin (Cana)-treated HUVECs. Results are mean ± SEM (n = 3). (B) AdCyclin A increased DNA synthesis in Cana-treated HUVECs. Cells were infected with AdCyclin A or AdGFP (50 MOI) for 24 h and then incubated in the absence or presence of Cana (50 μM) for another 24 h prior to measuring DNA synthesis. Results are mean ± SEM (n = 6). *Statistically significant effect of canagliflozin. ⁺Statistically significant effect of AdCyclin A.