Figure 2.
Replication of GII.4 genotype HuNoVs is prevented by pretreatment with either anti-GII.4 or anti-GII.17 pAbs. Before inoculation of IECs, 2 × 106 genome equivalents of each HuNoV genotype was incubated with 100 ng of (A) anti-GII.4 or (B) anti-GII.17 Ab, or with normal rabbit immunoglobulin G, for 1.5 hours. Inoculation, sampling, and quantification of genome equivalents were done as described in the Materials and Methods. Each value is representative of at least 3 independent experiments and is shown as the mean ± SD from between 4 and 6 wells of supernatants of each culture group. *P < .05. hpi, hours postinfection.