Table 5.
Post hoc analysis of pressure indices in stable CAD and ACS patients.
| Studied pressure indices | Stable CAD patients (n = 45) | ACS patients (n = 35) |
|---|---|---|
| Correlation | ||
| Whole cycle Pd/Pa vs FFR | +0.88 | +0.78 |
| iFR vs FFR | +0.81 | +0.74 |
| Contrast-FFR vs FFR | +0.76 | +0.81 |
| Area under curve by ROC analysis (against FFR≤ 0.80) | ||
| Whole cycle Pd/Pa | 0.98 (0.94–1) | 0.88 (0.76–0.99) |
| iFR | 0.96 (0.92–1) | 0.79 (0.64–0.96) |
| Contrast-FFR | 0.94 (0.87–1) | 0.88 (0.76–0.98) |
| Diagnostic accuracy (against FFR≤ 0.80) | ||
| Whole cycle Pd/Pa (<0.94) | 87% | 80% |
| iFR (<0.90) | 89% | 77% |
| Contrast-FFR (<0.88) | 91% | 77% |
FFR, fractional flow reserve using adenosine; contrast-FFR, fractional flow reserve using contrast; iFR, instantaneous wave-free ratio; CAD, coronary artery disease; ACS, acute coronary syndrome; ROC, receiver–operating characteristic analysis; Pd/Pa, the ratio of mean distal coronary pressure (Pd) to the mean pressure observed in the aorta (Pa).