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. 2019 Apr 16;13:112. doi: 10.3389/fncel.2019.00112

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Copyright © 2019 Rotermund, Schulz, Hirnet and Lohr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of action of adenosine in mitral cells. (A) Simplified neuronal network in the olfactory bulb. (B) Opening of two-pore domain potassium channels (K2P) by activation of A₁ receptors leads to hyperpolarization of mitral cells (MC). (C) A₁ receptor-mediated reduction of Ca²⁺ influx into presynaptic sites of MC reduces dendro-dendritic inhibition at reciprocal synapses between MC and interneurons (IN; GC and parvalbumin-positive interneurons). Abbr.: Ado, adenosine; Glu, glutamate; GC, granule cells; PG, periglomerular interneuron; PV, parvalbumin-positive interneuron; VACC, voltage-activated calcium channel. Illustration by SciGraphics.