Fig. 1.

Mean change from baseline in ANC ± s.e. by treatment and visit in (A) ASCERTAIN (weeks 1–24), (B) Study 1309 (days 1–29) and (C) Study 1309 (days 1–7)

^aPatients in the 4/8 mg/kg q4w i.v. group increased their dose to 8 mg/kg at week 4 and remained on 8 mg/kg for the remainder of the study. ^bThere were four sampling points on day 1: baseline, 1 h, 4 h and 8 h after dosing. ANC: absolute neutrophil count; BL: baseline; q2w: every 2 weeks; q4w: every 4 weeks.