Fig. 3.

Change in mSASSS between (A) Baseline to Wk104, (B) Wk104 to Wk208, (C) Baseline to Wk208

*Includes 23 patients (22 patients of whom had X-ray data at baseline, Wk104 and Wk208) whose dose was up-titrated from secukinumab 75 mg to 150 mg at various timepoints starting at Wk168. mSASSS score ranges from 0–72; higher scores indicate greater radiographic damage. Δ represents mean (s.d.) difference in mSASSS between timepoints. Baseline and Wk104 X-rays were re-read with Wk208 X-rays to minimize longitudinal variability. BL: baseline; IV: intravenous; mSASSS: modified Stoke Ankylosing Spondylitis Spine Score; n: number of patients with assessments at both timepoints; Wk: week.