. 2019 Mar 29;32(2):99–109. doi: 10.1089/jamp.2018.1467

Table 4.

Paclitaxel Pharmacokinetic Profiles

Group	Average paclitaxel aerosol concentration μg/L (std dev)	Dose mg/kg (std dev)	Plasma				Lung tissue
Group	Average paclitaxel aerosol concentration μg/L (std dev)	Dose mg/kg (std dev)	C_max ng/mL (std dev)	T_1/2 hours	AUC_(last) hr^ng/mL*	AUC_D(last) hr^ng^mg/mL^kg*	C_max ng/g (std dev)	T_1/2 hours	AUC_(last) hr^ng/g*	AUC_D(last) hr^ng^mg/g^kg*
IVnP	N/A	2.9 (0.16)	206 (44.1)	8.7	1,517	528	5,800 (430.1)	19.9	62,870	23,112
IHNP-LD	85.64 (8.76)	0.38 (0.003)	11.6 (3.5)	7.9	101	264	21,000 (3503.1)	56.3	342,877	914,095
IHNP-HD	262.27 (31.45)	1.18 (0.01)	15.9 (4.3)	8.6	228	193	41,600 (1557.8)	56.0	1,155,662	997,985

C_max, maximum concentration; T_1/2, apparent residence half-life; AUC_(last), exposure (area under the curve); AUC_D(last), dose-normalized exposure; std dev, standard deviation.