Table 2.
Overview of the traditional ESC-DF PTP and the corrected PROMISE PTP based on the observed prevalence in patients referred to non-invasive testing
| Sex/age (years) | Non-anginal chest pain (%) | Atypical angina (%) | Typical angina (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ESC-DF PTP | |||||||||||
| Men | |||||||||||
| 30–39 | 18 | 29 | 59 | ||||||||
| 40–49 | 25 | 38 | 69 | ||||||||
| 50–59 | 34 | 49 | 77 | ||||||||
| 60–69 | 44 | 59 | 84 | ||||||||
| 70–79 | 54 | 69 | 89 | ||||||||
| ≥80 | 65 | 78 | 93 | ||||||||
| Women | |||||||||||
| 30–39 | 5 | 10 | 28 | ||||||||
| 40–49 | 8 | 14 | 37 | ||||||||
| 50–59 | 12 | 20 | 47 | ||||||||
| 60–69 | 17 | 28 | 58 | ||||||||
| 70–79 | 24 | 37 | 68 | ||||||||
| ≥80 | 32 | 47 | 76 | ||||||||
| PROMISE PTP CAD ≥ 50% | |||||||||||
| Men | |||||||||||
| 30–39a | |||||||||||
| 40–49 | 2 (0.1–12.6) | 9 (5.9–13.1) | 13 (3.8–30.7) | ||||||||
| 50–59 | 16 (9.1–24.7) | 16 (13.5–18.9) | 21 (14.1–29.9) | ||||||||
| 60–69 | 15 (7.6–26.5) | 23 (19.4–27.0) | 30 (20.5–41.2) | ||||||||
| ≥70 | 21 (6.1–45.6) | 30 (22.7–37.5) | 48 (27.8–68.7) | ||||||||
| Women | |||||||||||
| 30–39a | |||||||||||
| 40–49a | |||||||||||
| 50–59 | 5 (1.5–10.7) | 6 (4.7–8.3) | 8 (3.4–14.9) | ||||||||
| 60–69 | 8 (3.9–15.2) | 11 (8.3–13.0) | 9 (4.2–16.4) | ||||||||
| ≥70 | 16 (6.2–32.0) | 17 (12.6–21.6) | 16 (7.2–29.1) | ||||||||
| PROMISE PTP CAD ≥ 70% | |||||||||||
| Men | |||||||||||
| 30–39a | |||||||||||
| 40–49 | 0 (0.0–8.4)a | 5 (2.5–7.9) | 10 (2.1–26.5) | ||||||||
| 50–59 | 5 (1.7–11.9) | 7 (5.1–8.9) | 9 (4.3–15.7) | ||||||||
| 60–69 | 6 (1.7–15.0) | 11 (8.6–14.3) | 19 (11.4–29.4) | ||||||||
| ≥70 | 5 (0.1–26.0) | 13 (7.9–18.9) | 40 (21.1–61.3) | ||||||||
| Women | |||||||||||
| 30–39a | |||||||||||
| 40–49a | |||||||||||
| 50–59 | 2 (0.2–6.7) | 3 (1.9–4.3) | 0 (0.0–3.6)a | ||||||||
| 60–69 | 3 (0.6–7.9) | 4 (2.9–6.0) | 1 (0.0–5.4) | ||||||||
| ≥70 | 8 (1.7–21.9) | 6 (3.5–9.3) | 8 (2.2–19.2) | ||||||||
The PROMISE PTP reflect the observed prevalence of CAD ≥ 50% and CAD ≥ 70% by coronary CTA. Values as percentages (95% CI). Colour-coding: low- (<15%, green), intermediate- (15–85%, yellow), and high-probability categories (>85%, orange).6
Women <50 years of age or men <45 years of age were not included in PROMISE trial. However, these patients were likely to have had low PTP, which is emphasized by the fact that the PTP of obstructive CAD in the next higher age group were low (men: 2–13%; women: 5–8%). Notably, in the PROMISE PTP, all men <50 years and women <70 years of age were categorized as low-probability (<15%) regardless of symptoms.
CAD, coronary artery disease; DF, Diamond and Forrester; ESC, European Society of Cardiology; PTP, pretest probability.