Jhanji 2010.

Methods	RCT Single centre
Participants	135 patients (3 arms) 45 patients in each arm Elective Gastrointestinal surgery
Interventions	Postoperative 3 arms to the study (arm‐1 CVP group fluid optimisation according to CVP, arm‐2 SV fluid optimization according to SV, third arm had fluids and continuous dopexamine infusion) LidCO Goals = SV
Outcomes	Microvascular flow and oxygenation Complications Infections Acute kidney injury Cardiac complications Critical care free days HLOS Hospital mortality
Notes	The 3rd arm with continuous dopexamine infusion is not included in the analysis as the control group was not matched
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"Participants were randomly allocated to one of three treatment groups by computer‐generated random sequence in blocks of nine"
Allocation concealment (selection bias)	Low risk	"The study group allocations were placed in serially numbered opaque envelopes"
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	"Only the member of the research team who delivered the intervention was aware of the study group allocation"
Blinding of outcome assessment (detection bias) All outcomes	Low risk	"Clinical outcomes data for each patient were collected by a member of the research team who was unaware of study group allocation"
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	Low risk	Published report includes all expected outcomes
Other bias	Unclear risk	Study was supported by pharmaceutical company