Lobo 2000.

Methods	RCT Single centre
Participants	37 patients 2 groups Elective surgery General surgery Vascular surgery
Interventions	Intra and postoperative Fluids and inotropes Pulmonary artery catheter Goals = DO2I
Outcomes	28 day and 60 day mortality HLOS ICULOS Sepsis, shock, septic shock, cardiogenic shock, nosocomial infection, acute pancreatitis, postoperative fistula, arrhythmia, cerebrovascular accident, deep vein thrombosis, gastrointestinal bleeding, hypothermia, sepsis‐related organ failure assessment (SOFA) score, bronchopneumonia, urinary tract infection, wound infection. ventilator days, organ dysfunction
Notes	Both groups had PAC and protocol group aimed to achieve supranormal DO2I
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Patients were randomized at the preoperative stage by means of sealed opaque envelopes"
Allocation concealment (selection bias)	Low risk	See quote above
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not detailed
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not detailed
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	Low risk	Published report included all expected outcomes
Other bias	Low risk	No other potential source of bias identified