Noblett 2006.

Methods	RCT Single centre
Participants	103 patients 2 groups Elective surgery General surgery
Interventions	Intraoperative Fluids Goals = SV, FTc
Outcomes	Hospital mortality HLOS ICULOS Surgical fitness for discharge, return of gastrointestinal function, flatus, bowel movement, food tolerance, readmission rate, cytokine markers of the systemic inflammatory response
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Double blind randomized controlled trial"; the method of randomization not mentioned
Allocation concealment (selection bias)	Unclear risk	See above quote, the method of allocation concealment not mentioned
Blinding of participants and personnel (performance bias) All outcomes	Low risk	"Doppler probe insertion and monitoring, and trial fluid administration were carried out by a medically qualified researcher who had no involvement in postoperative patient care or decision making"
Blinding of outcome assessment (detection bias) All outcomes	Low risk	See quote above
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing data
Selective reporting (reporting bias)	Low risk	All outcomes data were presented
Other bias	Unclear risk	Five patients excluded after allocation may have induced selection bias