Van der Linden 2010.

Methods	RCT Single centre
Participants	37 patients 3‐arm study High risk (ASA II‐III) Peripheral artery bypass grafting
Interventions	Intraoperative Fluids and Inotropes (dobutamine) FloTrac Vigileo monitor Goal = CI
Outcomes	Mortality HLOS Complications (infections)
Notes	The study comprised of 3 groups. Group 1: controls, Group 2: goal directed therapy and Group 3: goal directed therapy with different anaesthetic compared to group 1 and 2. As Group 3 was not matched with controls this was not included in the analysis.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"Patients were randomly assigned to three groups using computer generated random code"
Allocation concealment (selection bias)	Low risk	"The assignment was concealed in an envelope"
Blinding of participants and personnel (performance bias) All outcomes	Low risk	"The attending anaesthesiologist was blinded for the data displayed by the Vigileo monitor. Cardiac index data in these patients were recorded by an independent observer who was not involved in the patients treatment"
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Data were analysed blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing data
Selective reporting (reporting bias)	Low risk	All expected outcomes were reported
Other bias	Low risk	No other potential sources of bias identified