Wilson 1999.

Methods	RCT single centre
Participants	138 patients 3 groups Elective surgery General surgery Vascular surgery
Interventions	Preoperative Fluids and inotropes Pulmonary artery catheter Goals = DO2I
Outcomes	Hospital mortality HLOS ICULOS (Costs reported separately) Respiratory (prolonged weaning, adult respiratory distress syndrome (ARDS), pleural effusion, secondary ventilation, sputum retention), cardiovascular (myocardial infarction, arrhythmia, cardiac arrest, pulmonary embolus, cerebrovascular accident, transient ischaemic attack, cardiac failure), gastrointestinal (infarction, haemorrhage), acute renal failure, coagulopathy, infection (bacteraemia, sepsis syndrome, septic shock, respiratory sepsis, urinary sepsis, abdominal sepsis, wound sepsis, line sepsis, other sepsis), surgical (anastomotic breakdown, deep haemorrhage, wound haemorrhage)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"Random sequence was generated from a Unix computer program"
Allocation concealment (selection bias)	Low risk	"Allocation was concealed until trial entry by sealed opaque envelope"
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	" We were unable to effect true blinding between patients in the control and treatment groups"
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	See quote above
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing data
Selective reporting (reporting bias)	Low risk	All anticipated outcome data were reported
Other bias	Low risk	No other potential sources of bias