Study	Reason for exclusion
Alia 1999	Severe sepsis, septic shock
Balogh 2003	Trauma
Benes 2010	Patients not had surgery also included in the analysis
Bishop 1995	Trauma
Blow 1999	Trauma
Chang 2000	Trauma, not RCT
Chytra 2007	Trauma
Durham 1996	Established critical illness
Flancbaum 1998	Retrospective, not RCT
Fleming 1992	Trauma
Forget 2010	Pulse pressure variation is not a surrogate of global blood flow
Gattinoni 1995	Established critical illness
Gutierrez 1992	pHi guided
Hayes 1994	Established critical illness
Ivatury 1996	Trauma
Jammer 2010	Restricted goal directed fluid administration
Jorgensen 2009	Not RCT
Lobo 2006	Same flow goal in each group
Miller 1998	Trauma
Muller 1999	No explicit flow goal
Pargger 1998	pHi guided
Rivers 2001	Severe sepsis and septic shock
Scalea 1990	Trauma
Schilling 2004	Same flow goal in each group
Schultz 1985	No explicit flow goals
Stewart 2009	Retrospective study
Stone 2003	No explicit flow goals
Szakmany 2005	Intrathoracic blood volume goal
Takala 2000	No explicit flow goals
Tuchschmidt 1992	Septic shock
Velmahos 2000	Trauma
Wenkui 2010	Restricted fluid regimen
Yu 1993	Established critical illness
Yu 1995	Established critical illness
Yu 1998	Established critical illness