Table 4.

Age, sex, health status and clinical details of HHCs diagnosed with active TB disease

HHC	Age	Sex	Symptoms at screening	TB Dx in index case	Mal-nutrition	Immuno-deficiencyd	Active TB diagnosis in HHCse	TB Site(s)	Diagnostic resultsf
Amhara Region
1	58	M	Cough, night sweats, weight loss, appetite loss, fatigue	SS + PTB	No	No	EPTB	Cervical	AFB-negative SSM, normal CXR, suggestive FNAc
2	53	M	Cough, night sweats, fatigue	EPTB	No	No	EPTB	Pleural	Abnormal CXR, suggestive body fluid analysis
3	2	M	Fever, appetite loss	SS + PTB	Yes	No	PTB, no SSM	Pulmonary	Abnormal CXR
4a	11	M	Fever, night sweats, weight loss, appetite loss	SS + PTB	No	No	PTB, no SSM	Pulmonary	Abnormal CXR
5a	23	F	Cough, fever, night sweats, weight loss, appetite loss, fatigue	SS + PTB	No	No	SS + PTB	Pulmonary, cervical	AFB-positive SSM, abnormal CXR, suggestive FNAc
6a	40	F	Cough, fever, night sweats, weight loss, appetite loss, fatigue	SS + PTB	No	No	EPTB	Pleural	AFB-negative SSM, abnormal CXR, suggestive FNAc, suggestive U/S
7	14	F	Cough, neck swelling	EPTB	Yes	No	EPTB	Cervical	Suggestive FNAc
8	55	M	Cough, fever	SS-PTB	Yes	Yes	SS-PTB	Pulmonary	AFB-negative SSM, abnormal CXR
9	14	F	Cough, fever, night sweats, haemoptysis	EPTB	Yes	No	PTB, no SSM	Pulmonary	Abnormal CXR
10	5	M	Cough, fever, appetite loss	EPTB	No	No	PTB, no SSM	Pulmonary	Abnormal CXR
11	28	F	Fever, night sweats	EPTB	Yes	No	EPTB	Hilar lymph-adenopathy	Abnormal CXR
12	30	F	Cough, fever, fatigue	EPTB	Yes	Yesc	EPTB	Axillary lymph-adenopathy	Normal CXR, suggestive FNAc
13	8	M	Night sweats	EPTB	No	No	PTB, no SSM	Pulmonary, cervical	Abnormal CXR, suggestive FNAc
14b	60	F	Cough, fever, night sweats, weight loss, appetite loss, fatigue	EPTB	Yes	No	EPTB	Pleural, cervical	AFB-negative SSM, abnormal CXR, suggestive FNAc
15b	20	F	Cough, fever, night sweats	EPTB	Yes	Yes	PTB, no SSM	Pulmonary	Abnormal CXR
16	10	M	Cough, fever, night sweats, appetite loss	EPTB	Yes	No	PTB, no SSM	Pulmonary	Abnormal CXR
17	15	F	Cough, fever, night sweats, weight loss, neck swelling, fatigue	EPTB	Yes	No	PTB, no SSM	Pulmonary	Abnormal CXR, suggestive FNAc
18	4	F	Fever, night sweats	EPTB	No	No	PTB, no SSM	Pulmonary	Abnormal CXR
Tigray Region
19	14	F	Cough, weight loss	SS + PTB	Yes	No	SS + PTB	Pulmonary	AFB-positive SSM, abnormal CXR

^a, ^b Observed clustering (HHCs within the same household)

^cOnly HHC diagnosed with active TB disease with a positive HIV status

^dSelf-reported; includes HIV, kidney disease, diabetes, previous/current cancer treatment, previous TB, signs of primary immunodeficiency (e.g., recurrent or chronic infections)

^eSS-PTB Smear-negative pulmonary TB, SS + PTB smear-positive pulmonary TB, PTB pulmonary TB, no SSM sputum smear microscopy not performed, EPTB extra pulmonary TB

^fAFB acid-fast bacilli, SSM sputum smear microscopy, CXR chest x-ray, FNAc fine needle aspiration cytology, U/S ultrasound