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. 2019 Apr 23;26:28. doi: 10.1186/s12929-019-0520-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Schematic structure of oncoprotein E6. Protein structure and functions of HPV16 E6. Four zinc-binding motifs are indicated as grey boxes. The two zinc fingers are shown together with regions that are involved in interacting with some of its cellular target proteins. E6 contains PDZ domain–binding motif at its C-terminal extremity and three Nuclear localization signals (NLS). Functions associated with proteins in different regions are indicated by arrows