Fig. 2.

ADE levels of complement regulatory proteins in cross-sectional control, MCI, and AD groups. Each point represents the value for a control or patient, and the horizontal line in point clusters is the mean level for that group. Mean ± SEM for control, MCIS, MCIC, and AD patient values, respectively, are 35,166 ± 3981, 11,486 ± 1581, 2796 ± 230, and 3825 ± 499 pg/mL for DAF; 62.4 ± 5.48, 245 ± 37.3, 47.1 ± 4.78, and 35.3 ± 2.91 pg/mL for CD46; 473 ± 38.2, 475 ± 51.9, 268 ± 29.9, and 286 ± 20.6 pg/mL for CR1; and 1268 ± 84.1, 865 ± 103, 584 ± 60.6, and 353 ± 38.5 pg/mL for CD59. The significance of differences between values for controls and AD patients, and between values for MCIS and MCIC patients, was calculated by an unpaired Student's t-test and shown over the last two bars of each set; ⁺ = P < .05, * = P < .01, and ** = P < .0001. Abbreviations: ADE, astrocyte-derived exosome; AD, Alzheimer's disease; MCI, mild cognitive impairment; MCIC, MCI that converted to dementia; MCIS; stable MCI.