Table 1.

Characteristics of the study groups

	Previous study [19]		This study
Variable	Rituximab	Placebo	Rituximab	Placebo	p-valued
No. of subjects	55	30	37	17	NS
No. of samples	NA	NA	135	60	NA
Gender
M	35	18	25	11	NS
F	20	12	12	6	NS
Agea	19.8 + 8.6	17.9 + 7.9	22.2 + 8.3	21 + 3 + 9.0	NS
Initial C-peptideb	0.75 + 0.39	0.74 + 0.37	0.80 + 0.43	0.89 + 0.40	NS
Rate of C-peptide lossc	−0.46 + 0.45	−0.69 + 0.66	−0.38 + 0.33	−0.63 + 0.62	NS

Shown is a comparison of subject characteristics in the previously described in the rituximab trial [19] with those analyzed in this study (i.e., those giving good quality RNA-seq libraries). Plus–minus values are means ± SD

NA not applicable, NS not significant (p-value > 0.05)

^aYears

^bnmol/L/min

^cLog(nmol/L/min)/year

^dt-test for differences in this studt with previous study