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. 2018 Nov 8;24(4):484–490. doi: 10.1038/s41380-018-0289-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Effects of ASD GRS (at a p-value threshold of 0.05) on MADRS-S scores during iCBT treatment. The figure shows the predicted MADRS-S score for every week during treatment for three different levels of the ASD GRS (25th, 50th, and 75th percentiles). The shaded areas show the 95% confidence intervals of the predicted values. The participants with the highest ASD GRS scores (blue) showed poorer responses to treatment vs. those with average (green) or low (red) ASD GRS scores. Abbreviations: autism spectrum disorder (ASD), genetic risk score (GRS), Montgomery Åsberg Depression rating scale-Self (MADRS-S), internet-delivered cognitive behavior therapy (iCBT)