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. 2019 Mar 4;68(5):1084–1093. doi: 10.2337/db17-0821

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© 2019 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Mitochondrial respiration, response to glucose, and β-cell functions related to thiamine-dependent enzymes. A: Mitochondrial respiration profile of MIN6-m9 cells as measured by oxygen consumption rate (OCR). Data are means ± SD of four independent experiments. *P < 0.05. B: Insulin released from MIN6-m9 under physiological and glucose-stimulated conditions. Data are means ± SD of four independent experiments. *P < 0.05. **P < 0.0001. C: Analysis of oxidative stress–induced apoptosis. Data are means ± SD of three independent experiments. *P < 0.05. D: MIN6-m9 proliferation rate. Representative images of EdU (green) with overlay of Hoechst 33258 (blue) staining for nucleus. Pink boxes in the middle panels indicate areas shown at higher magnification in the right panels. Arrows indicate localizing of EdU and Hoechst. Scale bars = 50 μm. Data are means ± SD of three independent experiments. *P < 0.05.