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lnc-Leptin (Lnc-Lep) mediates the interaction between the enhancer and promoter of Leptin. lnc-Leptin is transcribed from an enhancer region ∼10 kb upstream Leptin promoter. In this model, the enhancer can form a long-distance loop with the promoter to promote a more active chromatin architecture for leptin transcription. lnc-Leptin is likely to play a role in the formation of the enhancer–promoter interaction.
