Table 1.
lncRNAs regulating brown- and beige-selective programs
| lncRNA | Role in BAT and WAT browning | Proposed mechanism of action | Ref. |
|---|---|---|---|
| Blnc1 | Positive | Interacts with EBF2 and Zbtb7b and hnRNPU to form ribonucleoprotein complexes to activate thermogenic gene expression | (49,53,54,58) |
| lncBATE1 | Positive | Interacts with hnRNPU to form a ribonucleoprotein complex | (37) |
| lncBATE10 | Positive | Decoys Celf1 from PGC-1α, thereby protecting PGC-1α mRNA from repression by Celf1 | (60) |
| UC.417 | Negative | Inhibits phosphorylation of p38MAPK | (89) |
| AK079912 | Positive | Unknown | (90) |
| H19 | Positive | Recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper | (63) |
| GM13133 | Negative | Unknown | (91) |