Table 2.
lncRNAs regulating white adipocyte adipogenesis and function
| lncRNA | Role in adipogenesis | Proposed mechanism of action | Ref. |
|---|---|---|---|
| SRA | Positive | Coactivates PPARγ | (68–70) |
| lncRAPs | Positive | Unknown | (71) |
| FIRRE | Positive | Interacts with hnRNPU to organize nuclear structure | (57) |
| PU.1 AS | Positive | Prevents PU.1 mRNA translation through forming mRNA/AS lncRNA duplex | (92,93) |
| lnc-U90926 | Negative | Inhibits PPARγ2 promoter transactivation | (94) |
| Gm15290 | Positive | Acts as a sponge for miR-27b | (95) |
| Paral1 | Positive | Coactivates PPARγ through interaction with the paraspeckle component and hnRNP-like RNA binding protein 14 (RBM14/NCoAA) | (96) |
| TCONS_00041960 | Negative | Acts as a sponge for miR-204-5p and miR-125a-3p | (97) |
| lnc-Leptin | Positive | Mediates the distant interaction between an enhancer and leptin promoter | (73) |
| Malat1 | No | Unknown | (78) |
| GAS5 | Negative | Acts as a microRNA sponage to repress miR-21a-5p and miR-18a | (98,99) |
| AdipoQ AS lncRNA | Negative | Suppresses AdipoQ mRNA translation via formation of AdipoQ AS lncRNA/AdipoQ mRNA duplex | (100) |
| Plnc1 | Positive | Reduces the methylation level of CpG region in the PPARγ2 promoter and enhances the transcriptional activity of the promoter | (74) |