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. 2019 Mar 4;68(5):988–1001. doi: 10.2337/db18-0686

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© 2019 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Upregulated protein and mRNA species in β-cells from donors with type 1 diabetes from the Class II processing and presentation pathway. The observed upregulated proteins and mRNA species from the Class II processing and presentation pathway of β-cells from donors with type 1 diabetes are displayed according to their intracellular locations and with their functions. Depicted by symbols with black borders are upregulated proteins (red circles) and mRNA species (red rectangles), whereas putative upregulated proteins identified by upregulated mRNA species are shown with red ovals, diamonds, or elongated ovals. Gray ovals depict mRNA species that were detected but not upregulated in the β-cells from islets of donors with type 1 diabetes.