Table 11.

Epigenetic dysregulation in Parkinson’s disease: non-coding RNAs.

Regulation	ncRNA	Observed in	Sample size	Approach	Methods	Reference
↓	miR-7	HEK293T, SH-SY5Y, NS20Y cell lines	-	Targeted (2 miRNAs)	PCR	Junn et al., 2009
≠	miR-10a	Mouse model	3	Targeted	miRNA expression profiling	Gillardon et al., 2008
≠	miR-10b	(overexpressing		(266 miRNAs)	(microfluidic chips)
≠	miR-132	A30P α-synuclein)
≠	miR-212
≠	miR-495
↓	miR-205	sPD patients	8	Targeted (1 miRNA)	PCR	Cho et al., 2013
≠	miR-1	Healthy individuals and	8	Targeted	PCR	Margis et al., 2011
≠	miR-22*	untreated PD patients		(85 miRNAs)
≠	miR-29
≠	miR-16–2*	Treated and untreated	7 treated
≠	miR-26a2*	PD patients	8 untreated
≠	miR-30a

^↓indicates decreased expression levels and

^≠indicates altered expression, not further specified.

Abbreviations: (s)PD, (sporadic) Parkinson’s disease; HEK293T cells, human embryonic kidney cell line; miR, micro RNA; NS20Y, mouse cholinergic neuroblastoma cell line; PD, Parkinson’s disease; SH-SY5Y cells, human neuroblastoma cell line; PCR, polymerase chain reaction.