Table 12.

Epigenetic dysregulation in Huntington’s disease: non-coding RNAs.

Regulation	ncRNA	Observed in	Sample size	Approach	Methods	Reference
↓	miR-22	HD murine models [YAC12	12 (mouse model)	Targeted	miRNA microassay	Lee et al., 2011
↓	miR-29c	and R6/2 mouse model,	18 (rat model)	(567 miRNAs)
↓	miR-125b	3NP-induced rat model; Striatum]
↓	miR-128
↓	miR-132
↓	miR-139
↑	miR-146a
↓	miR-150
↓	miR-218
↓	miR-222
↓	miR-344
↓	miR-674
↓	Drosha

^↑indicates increased expression levels and

^↓indicates decreased expression levels.

Abbreviations: FVB-Tg(YAC128)53Hay/J mice, transgenic mouse model generated with a yeast artificial chromosome (YAC) containing the human Huntingtin gene with 128 cytosine-adenine-guanine repeats; HD, Huntington’s disease; miR(NA), micro RNA.