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. Author manuscript; available in PMC: 2019 Apr 23.
Published in final edited form as: Prog Neurobiol. 2015 Jun 11;131:21–64. doi: 10.1016/j.pneurobio.2015.05.002

Table 9.

Epigenetic dysregulation in Huntington’s disease: chromatin remodeling.

Chromatin remodeling target Regulation Epigenetic modification Observed in Sample size Methods Reference
Histones (Globally) ≠ Acetylation HD mouse model
(R6/2 mouse model)		 N.S. WB Ferrante et al., 2004
H3K9 ↑↑ Tri-Methylation HD mouse model (R6/2 10 RT-PCR, Histone Ryu et al., 2006
HD mice; striatal neurons) Methylation Assay
HD patients (striatum) 6
↑

indicates increased expression levels and

≠

indicates a genetic mutation affecting epigenetic regulation.

Abbreviations: H, histone; HD, Huntington’s disease; K, lysine; R6/2 mice, transgenic mouse model overexpressing exon 1 of human HTT with an expanded cytosine-adenine-guanine repeat length; N.S., not specified; WB, Western blot; RT- PCR, real-time PCR.