The restoration of miR-641 level reduced the si-CRNDE#2-mediated anti-proliferation and pro-apoptosis effects on NSCLC cells. si-NC, si-CRNDE#2, si-CRNDE#2+miR-NC inhibitors, or si-CRNDE#2+miR-641 inhibitors were transfected into H1299 and SPC-A1 cells, followed by measurement of miR-641 expression (A, D), cell proliferation ability (B, E), and apoptosis capacity (C, F). * P<0.05 vs. si-NC or si-CRNDE#2+miR-NC inhibitors.