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. Author manuscript; available in PMC: 2019 Apr 23.
Published in final edited form as: Aliment Pharmacol Ther. 2015 Aug 3;42(7):912–921. doi: 10.1111/apt.13347

Table 1.

Baseline Characteristics of Patients Who Died and Those Alive at the end of Follow-up

Patients Alive at End
of Follow-up
(n=225)		 Patients Who
Died
(n=22)		 P-Value♦
Age (Years)* 35.7 (18–70)
 41.2 (18–74)
 0.03
Follow-up (Months)* 27 (1.3–4.9) 20 (0.1–45) 0.012
Male 87 (39%) 12 (55%) 0.15
SCD Genotype
SS
SC
Other 		181 (80%)
38 (17%)
6 (3%)		 17 (77%)
4 (18%)
1 (5%)		 0.86
SCD Complications
 >12 Pain Crises/Year
 Stroke
 Leg Ulcers
 Priapism
 >10 Lifetime Transfusions
 Severe Pulmonary
 Hypertension**
94 (48%)
38 (17%)
48 (22%)
34 (40%)
75 (43%)
23 (10%)
13 (59%)
1 (5%)
4 (21%)
6 (60%)
4 (50%)
6 (21%)
0.14
0.15
0.91
0.24
0.70
0.02
Body Mass Index [kg/m2]* 25.4 (4.0) 25.1 (8.7) 0.89
Baseline Lab Values
Hematologic (SD)*
Hemoglobin (g/dL)
White Blood Count (1,000/μL)
Platelets (1,000/μL)
Renal*
Creatinine (mg/dL)
Blood Urea Nitrogen (mg/dL)
Iron Indices*
Serum Iron (μg/dL)
Ferritin (μg/L)
Transferrin (mg/dL)
Liver*
ALT (U/L)
 >ULN n(%)
AST (U/L)
 >ULN n(%)
ALP (U/L)
 >ULN n(%)
LDH (U/L)
Albumin (g/L)
 >ULN n(%)
Bilirubin - Direct (mg/dL)
  >ULN n(%)
Total (mg/dL)
  >ULN n(%)

9.5 (1.8)
10.0 (3.5)
353 (133)

0.84 (1.0)
10.3 (10)

99 (53)
754 (1137)
209 (52)

26 (14)
30 (14)
40 (21)
107 (50)
109 (84)
71 (33)
352 (168)
4.1 (0.4)
44 (20)
0.44 (0.3)
115 (53)
2.6 (1.8)
179 (83)

9.1 (2.0)
12.3 (5.0)
384 (149)

1.51 (2.9)
14.6 (11)

125 (56)
2125 (2096)
175 (51)

32 (17)
6 (29)
48 (25)
14 (67)
173 (86)
15 (17)
383 (136)
3.8 (0.4)
10 (48)
0.83 (0.7)
18 (86)
2.6 (1.5)
19 (90)

0.38
0.006
0.32

0.023
0.07

0.053
<0.0001
0.005

0.10
0.10
0.11
0.17
0.001
0.001
0.44
0.0004
0.011
<0.0001
0.005
0.95
0.54
Viral Hepatitis^ (%)
Anti-HCV +ve
HBsAg +ve		 10/112 (9%)
1/115 (0.9%)		 2/6 (33%)
0/8 (0%)		 0.054
0.79
**

Pulmonary hypertension defined as tricuspid regurgitant jet > 2.5 m/s

^

Hepatitis B testing available in 123 and hepatitis C testing in 118 patients.

*

Mean (standard deviation), normal ranges of laboratory values are available at http://cclnprod.cc.nih.gov/dlm/testguide.nsf/HRRAll?OpenForm&Count=1183

♦

p-value calculated using student’s t-test for continuous variables or Fisher’s exact test for proportions.