. Author manuscript; available in PMC: 2019 Apr 23.

Published in final edited form as: Aliment Pharmacol Ther. 2015 Aug 3;42(7):912–921. doi: 10.1111/apt.13347

Table 2.

Cox Regression Analysis for Association with Mortality

Parameter^§	Unadjusted HR (95% CI)	Unadjusted P-value^*	HR (95% CI)^{^} Adjusted for PH and WBC	P-Value^* Adjusted for PH and WBC
Iron Indices
Log Ferritin Transferrin > 165 mg/dL ≤ 165 mg/dL Iron < 90 μg/dL ≥ 90 μg/dL	1.9 (1.4–2.7) 1.0 3.9 (1.6–9.2) 1.0 3.6 (1.3–10.4)	<0.0001 0.002 0.01	1.6 (1.2–2.3) 1.0 2.4 (0.91–6.1) 1.0 2.7 (0.93–8.0)	0.02 0.08 0.05
Liver Enzymes
ALT AST < 37 U/L ≥ 37 U/L Log ALP LDH <324 U/L ≥ 324 U/L	1.2 (1.0–1.5) 1.0 2.2 (0.89–5.5) 3.8 (2.0–7.1) 1.0 2.1 (0.78–5.4)	0.14 0.086 <0.0001 0.13	1.1 (0.98–1.5) 1.0 1.1 (0.40–3.0) 2.2 (1.0–4.5) 1.0 1.1 (0.40–3.0)	0.42 0.85 0.05 0.87
Liver Synthetic Function
Direct Bilirubin Total Bilirubin Albumin	2.8 (1.8–4.4) 1.0 (0.77–1.3) 0.16 (0.07–0.39)	<0.0001 1.0 <0.0001	2.4 (1.4–4.2) 0.90 (0.68–1.2) 0.29 (0.11–0.76)	0.02 0.47 0.02
Viral Hepatitis
Anti-HCV+	3.3 (0.59–17.9)	0.18	4.0 (0.65–25.1)	0.13

^§

Parameters were evaluated in regression models as continuous variables, by quartile and as dichotomous variables (dichotomized at median, or at the 25^th or 75^th percentile), as appropriate for the relationship with mortality

P-values calculated using likelihood ratio test

^{^}

Hazard ratios adjusted for presence of pulmonary hypertension and white blood cell count