Table 1.
Characteristics of the 3820 participants (5216 observations) from the Framingham Offspring and Third Generation cohorts.
| Characteristics | Offspring Cohort Mean(SD) or N[%] |
Third Generation Cohort Mean(SD) or N[%] |
Overall Mean(SD) or N[%] |
|
|---|---|---|---|---|
| Cycle 7 | Cycle 8 | Cycle 1 | ||
| Number of observations | 1846 | 1549 | 1821 | 5216 |
| Age, years | 61.7 (9.5) | 67.3 (9.1) | 40.1 (8.9) | 55.8 (14.9) |
| Women | 987 [53.5] | 836 [54.0] | 971 [53.3] | 2794 [53.6] |
| Body mass index, kg/m2 | 28.4 (5.3) | 28.6 (5.4) | 27.0 (5.6) | 28.0 (5.5) |
| Alcohol, drinks/week | 4.5 (7.0) | 4.0 (6.7) | 4.3 (6.2) | 4.3 (6.6) |
| Smoking status | ||||
| Non-smoker | 792 [42.9] | 665 [42.9] | 1255 [68.9] | 2712 [52.0] |
| Former smoker | 1054 [57.1] | 884 [57.1] | 566 [31.1] | 2504 [48.0] |
| Pack year | 14.1 (20.6) | 14.1 (20.6) | 3.5 (9.0) | 10.4 (18.2) |
| Educational attainmenta | ||||
| High school or less | 667 [36.1] | 549 [35.4] | 266 [14.6] | 1482 [28.4] |
| Some college | 563 [30.5] | 483 [31.2] | 575 [31.6] | 1621 [31.1] |
| College graduate | 586 [31.7] | 517 [33.4] | 976 [53.6] | 2079 [39.9] |
| Diabetes | 245 [13.3] | 288 [18.6] | 55 [3.0] | 588 [11.3] |
| Cardiovascular disease | 240 [13.0] | 263 [17.0] | 28 [1.5] | 531 [10.2] |
| Antihypertensive use | 681 [36.9] | 920 [59.4] | 186 [10.2] | 1787 [34.3] |
| Statins use | 422 [22.9] | 661 [42.7] | 124 [6.8] | 1207 [23.1] |
| CD40 ligandb, ng/ml | 1.6 (2.0) | - | - | 1.6 (2.0) |
| ICAM-1b,c, ng/ml | 244.8 (57.9) | 291.3 (91.4) | 240.1 (57.8) | 255.8 (70.5) |
| Interleukin-18b, pg/ml | 250.8 (94.6) | - | - | 250.8 (94.6) |
| LpPLA2 activityb,c, nmol/min/ml | 138.2 (34.4) | 134.2 (34.8) | 160.8 (36.6) | 144.5 (37.2) |
| LpPLA2 massb,c, ng/ml | 282.5 (89.8) | 192.5 (51.4) | 225.8 (46.2) | 233.2 (72.2) |
| MCP-1b,c, pg/ml | 312.4 (104.4) | 374.4 (116.2) | 331.1 (109.9) | 336.3 (112.6) |
| P-selectinb,c, ng/ml | 35.3 (13.3) | 39.1 (12.6) | 45.4 (16.8) | 39.7 (14.9) |
| Osteoprotegerinb,c, pmol/l | 5.4 (1.7) | 4.8 (1.6) | - | 5.1 (1.7) |
Abbreviation: SD, standard deviation; ICAM-1, intercellular adhesion molecule 1; LpPLA2, lipoprotein-associated phospholipase A2; MCP-1, monocyte chemoattractant protein 1.
30 (1.6%) and 4 (0.2%) participants in examination cycle 7 and 1, respectively, were missing educational attainment data and were assigned missing indicators.
Geometric mean and standard deviation.
1352 participants had two measurements of ICAM-1, 1376 participants had two measurements of LpPLA2 activity and LpPLA2 mass, 1328 participants had two measurements of MCP-1, 1395 participants had two measurements of P-selectin, and 1392 participants had two measurements of osteoprotegerin.