Ebbehøj 1985.
Methods | Randomised clinical trial | |
Participants | Country: Denmark Number randomised: 30 Postrandomisation dropouts: 0 (0%) Revised sample size: 30 Average age: 55 years Women: 10 (33.3%) Acute interstitial oedematous pancreatitis: not stated Necrotising pancreatitis: not stated Mild pancreatitis: not stated Moderate pancreatitis: not stated Severe pancreatitis: not stated Persistent organ failure: not stated Infected pancreatitis: not stated Inclusion criteria: people with acute pancreatitis | |
Interventions | Group 1: NSAID (n = 14), indomethacin 50 mg PR twice daily for 7 days Group 2: placebo (n = 16) | |
Outcomes | Hospital stay Follow‐up: not stated (probably until discharge) |
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Notes | — | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Comment: this information was not available. |
Allocation concealment (selection bias) | Unclear risk | Comment: this information was not available. |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Quote: "[c]ontrolled double‐blind trial". |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Quote: "[c]ontrolled double‐blind trial". |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Comment: there were no postrandomisation dropouts. |
Selective reporting (reporting bias) | High risk | Comment: either mortality or adverse events were not reported. |
For profit‐bias | High risk | Quote: "[i]ndomethacin (Confortid) and placebo were generously supplied by Dumex Ltd, Denmark". |
Other bias | Low risk | Comment: no other risk of bias |