Poropat 2015.

Methods	Randomised clinical trial
Participants	Country: Croatia Number randomised: 43 Postrandomisation dropouts: 0 (0%) Revised sample size: 43 Average age: not stated Women: not stated Acute interstitial oedematous pancreatitis: not stated Necrotising pancreatitis: not stated Mild pancreatitis: not stated Moderate pancreatitis: not stated Severe pancreatitis: not stated Persistent organ failure: not stated Infected pancreatitis: not stated Inclusion criteria People with acute pancreatitis APACHE II score ≥ 8
Interventions	Group 1: antibiotics (n = 23): imipenem 500 mg IV 3 times daily for 10 days Group 2: no intervention (n = 24)
Outcomes	Mortality, serious adverse events, adverse events, infected pancreatic necrosis, and organ failure Follow‐up: not stated (probably until discharge)
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Comment: this information was not available.
Allocation concealment (selection bias)	Unclear risk	Comment: this information was not available.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Comment: this information was not available.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Comment: this information was not available.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: there were no postrandomisation dropouts.
Selective reporting (reporting bias)	Low risk	Comment: mortality and adverse events were reported.
For profit‐bias	Unclear risk	Comment: this information was not available.
Other bias	Low risk	Comment: no other risk of bias