Van Wyk 1971.

Methods	Allocation: randomised Blindness: not blind Duration: 12 weeks Design: parallel Setting: hospital Country: South Africa
Participants	Diagnosis: schizophrenia and "toxic psychoses" N = 101 Age: adults (no further information provided) Sex: male History: acute psychoses, no epilepsy or depressive psychoses
Interventions	1. Clotiapine: 40 mg/d orally. N = 36 2. Chlorpromazine: 200 mg/d orally. N = 34 3. Thioridazine: 200 mg/d orally. N = 31
Outcomes	Service use: number discharged by 12 weeks Unable to use Mental state: general ‐ average endpoint score (scale not named ‐ unsure if peer reviewed) Adverse effects: adverse effects mentioned in text, but no data reported to support statements
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "Allocation to either of the 3 drug groups was at random"
Allocation concealment (selection bias)	Unclear risk	No information provided for allocation concealment
Blinding of participants and personnel (performance bias) All outcomes	High risk	Quote: "Because of the administrative and staff shortage problems we could not introduce· any 'blind' procedures into the trial"
Blinding of outcome assessment (detection bias) All outcomes	High risk	Quote: "Because of the administrative and staff shortage problems we could not introduce· any 'blind' procedures into the trial"
Incomplete outcome data (attrition bias) All outcomes	High risk	No information was provided for attrition and missing data
Selective reporting (reporting bias)	Unclear risk	No information was provided for pre‐specified outcomes
Other bias	Unclear risk	Clotiapine was supplied by a researcher from Switzerland. No source of funding reported

EPS: extrapyramidal symptoms
 F: female
 M: male
 N: number
 SD: standard deviation

Scales

PANSS: Positive and negative syndrome scale
 S‐Scale: Marten's Symptom scale
 CGI: Clinical Global Impression
 NOSIE: Nurses' Observational Scale for Inpatient Evaluation