Fig. 1.
Mechanism of action of novel anti-panic drugs at the synapse of the brain neuron. 1. Mirtazapine, nefazodone, risperidone inhibits postsynaptic receptors and prevent postsynaptic response. 2. Mirtazapine inhibit auto/heteroreceptor at the presynaptic neuron and promote subsequent neurotransmitter release. 3. Duloxetine, reboxetine, nefazodone inhibits the reuptake transporter to prevent neurotransmitter reuptake into the presynaptic neuron.
NE, norepinephrine; 5-HT, serotonin; D2, dopamine 2; H1, histamine 1.