Fig. 2.

Effect of Li₂CO₃ on baseline synaptic transmission in the dentate gyrus of hippocampal formation. The input-output curves were generated by plotting population spike (PS) amplitude and excitatory postsynaptic potential (EPSP) slope across a range of stimulation intensities (0.1–1.5 mA). Input-output (I/O) curves in A and B were taken prior to and after Li₂CO₃ (or saline) infusion from the same animal (n=5/group). I/O curves in C and D were prior to long-term potentiation induction in the lithium (Li) group and control group (n=7/group). PS and EPSP at each intensity level are mean of three consecutive responses in 5 rats for each group. Data are expressed as mean±standard error of mean. Note that the PS amplitude and EPSP slope were not different across the eight stimulus intensities as indicated by no significant interactions between intensity and drug.