Comparison 1. SPRM versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in symptom severity score (QoL)	4	171	Mean Difference (IV, Random, 95% CI)	‐20.04 [‐26.63, ‐13.46]
2 Change in health‐related quality of life score	4	200	Mean Difference (IV, Random, 95% CI)	22.52 [12.87, 32.17]
3 Change in menstrual blood loss	3	310	Std. Mean Difference (IV, Random, 95% CI)	‐1.11 [‐1.38, ‐0.83]
4 Amenorrhoea	7	590	Odds Ratio (IV, Random, 95% CI)	82.50 [37.01, 183.90]
5 Change in uterine volume	4	419	Std. Mean Difference (IV, Random, 95% CI)	‐0.63 [‐0.91, ‐0.36]
6 SPRM‐associated endometrial changes	5	405	Odds Ratio (IV, Random, 95% CI)	15.12 [6.45, 35.47]