Colson 1992.

Methods	Prospective randomized controlled trial
Participants	Scheduled for infrarenal aortic surgery because of aortic aneurysm (n = 8) or aorta occlusive disease (n = 16) Mean age (years): 1. 63 ± 1; 2. 63 ± 3; 3. 58 ± 4 Sample size (male): 24(23)
Interventions	2 days before surgery, participants were allocated to 1 of 3 groups in randomized, double‐blind fashion: 1. control group; 2. nicardipine group; 3. enalapril group. The enalapril group received enalapril (10 mg twice daily), whereas the control and nicardipine groups received a placebo (1 tablet twice daily). The last dose of either enalapril or placebo was given at the time of preanaesthetic medication, approximately 2 h before surgery. Both treatments were well tolerated. At skin incision, nicardipine was administered to the nicardipine group (2 mg IV bolus injection, then 2 mg/h), and placebo (5% glucose solution) was infused in participants in the other groups
Outcomes	Glomerular filtration rate
Notes	Intervention started 2 days before surgery and continued until 2 h before surgery
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Random allocation, but no details available
Allocation concealment (selection bias)	Unclear risk	No relevant description, and no further details available
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double blind, but no details available
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No relevant description
Incomplete outcome data (attrition bias) All outcomes	High risk	No relevant description
Selective reporting (reporting bias)	Unclear risk	Protocol inaccessible
Other bias	Unclear risk	Funding source not reported