Comparison 1. Inhaled tobramycin versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Positive respiratory culture for P aeruginosa (300 mg 2x daily)	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
1.1 At 1 month	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.2 At 2 months	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Positive respiratory culture for P aeruginosa (80 mg 2x daily)	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
2.1 At 1 month	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.2 At 2 months	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.3 At 3 months	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.4 At 6 months	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.5 At 12 months	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3 Positive respiratory culture for P aeruginosa (combined available case analysis)	2		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 At 1 month	2	38	Odds Ratio (M‐H, Fixed, 95% CI)	0.06 [0.01, 0.33]
3.2 At 2 months	2	38	Odds Ratio (M‐H, Fixed, 95% CI)	0.15 [0.03, 0.65]
4 Positive respiratory culture for P aeruginosa (combined) ‐ best case	2		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 At 1 month	2	39	Odds Ratio (M‐H, Fixed, 95% CI)	0.06 [0.01, 0.30]
4.2 At 2 months	2	39	Odds Ratio (M‐H, Fixed, 95% CI)	0.14 [0.03, 0.60]
4.3 At 3 months	1	18	Odds Ratio (M‐H, Fixed, 95% CI)	0.14 [0.02, 1.16]
4.4 At 6 months	1	18	Odds Ratio (M‐H, Fixed, 95% CI)	0.04 [0.00, 0.48]
4.5 At 12 months	1	18	Odds Ratio (M‐H, Fixed, 95% CI)	0.01 [0.00, 0.26]
5 Positive respiratory culture for P aeruginosa (combined) ‐ worst case	2		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 At 1 month	2	39	Odds Ratio (M‐H, Fixed, 95% CI)	0.08 [0.02, 0.38]
5.2 At 2 months	2	39	Odds Ratio (M‐H, Fixed, 95% CI)	0.18 [0.04, 0.73]
5.3 At 3 months	1	18	Odds Ratio (M‐H, Fixed, 95% CI)	0.36 [0.05, 2.77]
5.4 At 6 months	1	18	Odds Ratio (M‐H, Fixed, 95% CI)	0.16 [0.01, 1.83]
5.5 At 12 months	1	18	Odds Ratio (M‐H, Fixed, 95% CI)	0.36 [0.05, 2.77]
6 Weight (kg) ‐ change from baseline	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
6.1 At 1 month	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
6.2 At 2 months	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
7 Adverse events	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
7.1 Cough	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
8 Modified Shwachmann score ‐ change from baseline	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
8.1 At 1 month	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
8.2 At 2 months	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]