Date	Event	Description
19 April 2017	New citation required but conclusions have not changed	We have not been able to include data from any new trials at this update and our conclusions remain the same.
18 April 2017	New search has been performed	A search of the Cystic Fibrosis and Genetic Disorders Group's Cystic Fibrosis Trials Register identified 56 unique references possibly eligible for inclusion in the review. One reference (conference abstract) was a new ongoing trial (Ratjen 2016). Four references were added to an already included trial (Treggiari 2011). Eight references were added to four already excluded trials: four references (Goss 2009); one reference (Mainz 2014); two references (Wainwright 2011a); and one reference (Wainwright 2011b). Ten new trials (47 references) were excluded (Elborn 2015; Flume 2015a; Flume 2015b; Flume 2016; Geller 2011; Konstan 2011; Konstan 2015; Ruddy 2013; Stass 2013; Stockmann 2015). Two references described two of the trials and one reference described three of the trials ‐ these references are linked multiple times, once to each of the trials they describe. Summary of findings tables have been included in the review at this update.
29 October 2014	New search has been performed	A search of the Group's CF Register identified 117 references for possible inclusion in the review. Three references have been added to an already included trial (Proesmans 2013). One trial, known as the ELITE trial, has been moved from 'Ongoing studies' to 'Included studies' and the reference to the full publication added; this trial has provided a comparison of duration of intervention not previously available for inclusion (Ratjen 2010). A further trial also previously listed as ongoing with the study ID Ramsey 2005 (also known as the EPIC trial) has been included with 11 new references (Treggiari 2011). One new trial, with nine references has been included (Taccetti 2012). A total of 22 new trials (97 references) have been excluded: one reference each (Alothman 2005; Goss 2009; Prayle 2013; Postnikov 2007; Wainwright 2011b); two references each (Alothman 2002; Kenny 2009; Mainz 2014; Schelstraete 2010; Tramper‐Stranders 2009); three references each (Coates 2011; Geller 2007; Mazurek 2012; Rietschel 2009); four references each (Retsch‐Bogart 2008; Trapnell 2012); five references each (Clancy 2013; Konstan 2010); six references each (Oermann 2009; Schuster 2013); 10 references (Retsch‐Bogart 2009); and 32 references (Ramsey 1999). Two trials previously listed as 'Awaiting classification' have now been excluded (Latzin 2008; Lenoir 2007). One additional reference has been added to a previously excluded study (Wainwright 2011a) The full paper to an abstract already listed as 'Awaiting Classification' has now been published and added to the existing study ID while we await clarification regarding participants from the authors (Noah 2010). One new trial (with a single reference) has been added to 'Ongoing studies' (TORPEDO Trial). There have been three post hoc changes to the review at this update: we now include participants who have received treatment within six months of the first isolation of P. aeruginosa (previously not more than two months); we now allow trials where all patients receive some eradication therapy before randomisation which reflects current recommended 'standard of care' and consequent trial design; we have added cost as an outcome measure, as cost‐effectiveness has become increasingly important in CF care.
29 October 2014	New citation required but conclusions have not changed	This review has been updated, but the conclusions remain the same.
10 June 2009	New search has been performed	A new search of the Group's CF Register identified 14 new references. We have included one new study with one reference (Proesmans 2013) and excluded two new studies with three new references (Postnikov 2000; Steinkamp 2007). Three studies with a total of five references are listed as 'Awaiting classification' until we are able to obtain further details (Latzin 2008a; Lenoir 2007a; Noah 2007). We have added five references to the two ongoing studies: one reference to Ramsey 2005a and four references to Ratjen 2006a.
10 June 2009	New citation required but conclusions have not changed	From the 2009 update of this review, the lead author Dr Damian Wood has stepped down and is no longer involved in the review. The new lead author is Dr Simon Langton Hewer.
12 November 2008	Amended	Converted to new review format.
13 November 2007	Amended	The review authors have addressed some comments from the CFGD Group's medical statistician within this update.
13 November 2007	New search has been performed	The search identified four new trials; two of which have been excluded (Gibson 2007; Griese 2002); and two of which are still ongoing (Ramsey 2005a; Ratjen 2006a).
15 November 2006	Feedback has been incorporated	The review now contains the response from the authors to feedback regarding the necessity of further trials received through The Cochrane Library Feedback system.