Source	Search strategy	Hits retrieved
1. ALOIS (www.medicine.ox.ac.uk/alois) (Date of most recent search: 27 February 2019)	delirium	Jul 2012: 96 Apr 2013: 9 Nov 2016: 8 Feb 2018: 3 Feb 2019: 3
2. MEDLINE In‐process Nov 2016:and other non‐indexed citations and MEDLINE 1950 ‐ present (OvidSP) (Date of most recent search: 27 February 2019)	1. Delirium/ 2. deliri*.mp. 3. "acute confusion*".ti,ab. 4. "acute organic psychosyndrome".ti,ab. 5. "acute brain syndrome".ti,ab. 6. "metabolic encephalopathy".ti,ab. 7. "acute psycho‐organic syndrome".ti,ab. 8. "clouded state".ti,ab. 9. "clouding of consciousness".ti,ab. 10. "exogenous psychosis".ti,ab. 11. "toxic psychosis".ti,ab. 12. "toxic confusion".ti,ab. 13. Delirium, Dementia, Amnestic, Cognitive Disorders/su [Surgery] 14. obnubilat*.ti,ab. 15. or/1‐14 16. Primary Prevention/ 17. prevent*.mp. 18. reduc*.ti,ab. 19. stop*.ti,ab. 20. taper*.ti,ab. 21. avoid*.ti,ab. 22. "cut* down".ti,ab. 23. or/16‐22 24. 15 and 23 25. randomized controlled trial.pt. 26. controlled clinical trial.pt. 27. randomi?ed.ab. 28. placebo.ab. 29. drug therapy.fs. 30. randomly.ab. 31. trial.ab. 32. groups.ab. 33. or/25‐32 34. (animals not (humans and animals)).sh. 35. 33 not 34 36. 24 and 35	Jul 2012: 821 Apr 2013: 118 Nov 2016: 120 Feb 2018: 263 Feb 2019: 192
3. Embase 1980 ‐ 2019 February 26 (OvidSP) (Date of most recent search: 27 February 2019)	1. Delirium/ 2. deliri*.mp. 3. "acute confusion*".ti,ab. 4. "acute organic psychosyndrome".ti,ab. 5. "acute brain syndrome".ti,ab. 6. "metabolic encephalopathy".ti,ab. 7. "acute psycho‐organic syndrome".ti,ab. 8. "clouded state".ti,ab. 9. "clouding of consciousness".ti,ab. 10. "exogenous psychosis".ti,ab. 11. "toxic psychosis".ti,ab. 12. "toxic confusion".ti,ab. 13. Delirium, Dementia, Amnestic, Cognitive Disorders/su [Surgery] 14. obnubilat*.ti,ab. 15. or/1‐14 16. primary prevention/ 17. prevent*.mp. 18. reduc*.ti,ab. 19. stop*.ti,ab. 20. taper*.ti,ab. 21. avoid*.ti,ab. 22. "cut* down".ti,ab. 23. or/16‐22 24. 15 and 23 25. randomized controlled trial/ 26. random*.ti,ab. 27. placebo.ti,ab. 28. trial.mp. 29. controlled clinical trial/ 30. or/25‐29 31. 24 and 30	Jul 2012: 835 Apr 2013: 161 Nov 2016: 191 Feb 2018: 562 Feb 2019: 366
4. PsycINFO 1806 ‐ February week 4 2019 (OvidSP) (Date of most recent search: 27 February 2019)	1. Delirium/ 2. deliri*.mp. 3. "acute confusion*".ti,ab. 4. "acute organic psychosyndrome".ti,ab. 5. "acute brain syndrome".ti,ab. 6. "metabolic encephalopathy".ti,ab. 7. "acute psycho‐organic syndrome".ti,ab. 8. "clouded state".ti,ab. 9. "clouding of consciousness".ti,ab. 10. "exogenous psychosis".ti,ab. 11. "toxic psychosis".ti,ab. 12. "toxic confusion".ti,ab. 13. obnubilat*.ti,ab. 14. or/1‐13 15. Prevention/ 16. prevent*.mp. 17. reduc*.ti,ab. 18. stop*.ti,ab. 19. taper*.ti,ab. 20. avoid*.ti,ab. 21. "cut* down".ti,ab. 22. or/15‐21 23. 14 and 22 24. random*.mp. 25. trial.mp. 26. placebo*.mp. 27. group.ab. 28. or/24‐27 29. 23 and 28	Jul 2012: 163 Apr 2013: 19 Nov 2016: 16 Feb 2018: 45 Feb 2019: 17
5. CINAHL (EBSCOhost) (Date of most recent search: 27 February 2019)	S1 (MH "Delirium") OR (MH "Delirium Management (Iowa NIC)") OR (MH "Delirium, Dementia, Amnestic, Cognitive Disorders/SU") S2 TX deliri* S3 TX "acute confusion*" S4 TX "acute organic psychosyndrome" S5 TX "acute brain syndrome" S6 TX "metabolic encephalopathy" S7 TX "acute psycho‐organic syndrome" S8 TX "clouded state" S9 TX "clouding of consciousness" S10 TX "exogenous psychosis" S11 TX "toxic psychosis" S12 TX "toxic confusion" S13 TX obnubilat* S14 S1 or S2 or S3 or S4 or S5 or S6 or S7 or S8 or S9 or S10 or S11 or S12 or S13 S15 (MH "Preventive Trials") OR (MH "Preventive Health Care") S16 TX prevent* S17 TX reduc* S18 TX stop* S19 TX taper* S20 TX avoid* S21 TX "cut* down" S22 S15 or S16 or S17 or S18 or S19 or S20 or S21 S23 S14 and S22 S24 TX random* S25 TX placebo S26 TX trial S27 (MH "Clinical Trials") OR (MH "Intervention Trials") S28 S24 or S25 or S26 or S27 S29 S23 and S28	Jul 2012: 189 Apr 2013: 0 Nov 2016: 2 Feb 2018: 86 Feb 2019: 115
6. Web of Science Core Collection (ISI Web of Science) (Date of most recent search: 27 February 2019)	Topic=(deliri* OR "acute confusion*" OR "acute organic psychosyndrome" OR "acute brain syndrome" OR "metabolic encephalopathy" OR "acute psycho‐organic syndrome" OR "clouded state" OR "clouding of consciousness" OR "exogenous psychosis" OR "toxic psychosis" OR "toxic confusion" OR obnubilat*) AND Topic=(prevent* OR reduc* OR stop* OR taper* OR avoid* OR "cut* down") AND Topic=(random* or placebo or "double‐blind" or trial OR groups OR "controlled study" OR "time series" OR "Comparative Study" OR "Pretest‐Posttest Design") Timespan=All Years. Databases=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH, BKCI‐S, BKCI‐SSH. Lemmatization=On	Jul 2012: 654 Apr 2013: 163 Nov 2016: 176 Feb 2018: 620 Feb 2019: 325
7. LILACS (BIREME) (Date of most recent search: 27 February 2019)	randomly OR randomised OR randomized OR trial OR ensaio clínico OR control OR controlled [Words] and delirium OR delious OR deliria OR delirio OR loucura [Words]	Jul 2012: 47 Apr 2013: 1 Nov 2016: 5 Feb 2018: 8 Feb 2019: 6
8. CENTRAL (the Cochrane Library) (Issue 2 of 12, 2019) (Date of most recent search: 27 February 2019)	#1 MeSH descriptor Delirium, this term only #2 deliri* #3 "acute confusion*" #4 "acute organic psychosyndrome" #5 "acute brain syndrome" #6 "metabolic encephalopathy" #7 "acute psycho‐organic syndrome" #8 "clouded state" #9 "clouding of consciousness" #10 "exogenous psychosis" #11 "toxic psychosis" #12 "toxic confusion" #13 obnubilat* #14 (#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13) #15 MeSH descriptor Primary Prevention, this term only #16 prevent* #17 reduc* #18 stop* #19 taper* #20 avoid* #21 "cut* down" #22 (#15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21) #23 (#14 AND #22), trials	Jul 2012: 230 Apr 2013: 7 Nov 2016: 42 Feb 2018: 80 Feb 2019: 365
9. Clinicaltrials.gov (www.clinicaltrials.gov) (Date of most recent search: 27 February 2019)	care home OR institutionalised OR institutionalized OR long term care OR home | Interventional Studies | delirium OR toxic psychosis OR toxic confusion OR metabolic encephalopathy OR clouded state OR exogenous psychosis | Senior	Jul 2012: 156 Apr 2013: 23 Nov 2016: 11 Feb 2018: 27 Feb 2019: 12
10. ICTRP Search Portal (apps.who.int/trialsearch) (includes: Australian New Zealand Clinical Trials Registry; ClinicalTrials.gov; ISRCTN; Chinese Clinical Trial Registry; Clinical Trials Registry – India; Clinical Research Information Service – Republic of Korea; German Clinical Trials Register; Iranian Registry of Clinical Trials; Japan Primary Registries Network; Pan African Clinical Trial Registry; Sri Lanka Clinical Trials Registry; The Netherlands National Trial Register) (Date of most recent search: 27 February 2019)	care home OR institutionalised OR institutionalized OR long term care OR home | Interventional Studies | delirium OR toxic psychosis OR toxic confusion OR metabolic encephalopathy OR clouded state OR exogenous psychosis	Jul 2012: 72 Apr 2013: 0 Nov 2016: 1 Feb 2018: 5 Feb 2019: 1
TOTAL before deduplication		July 2012: 3263 April 2013: 501 Nov 2016: 572 Feb 2018: 1699 Feb 2019: 1037 TOTAL: 7027
TOTAL after deduplication and first assessment by CDCIG Information Specialists		July 2012: 120 April 2013: 15 Nov 2016: 31 Feb 2018: 70 Feb 2019: 2 TOTAL: 238