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MDM4 regulates p53 at three key levels. (A) MDM4 binds to wt p53 and inhibits its transcriptional activity in normal cells and when MDM4 is elevated in cancers. (B) MDM4 promotes MDM2 E3 ligase activity towards p53 during development. (C) MDM4 and also MDM2 promote p53 translation from its IRES in response to stress.
